Rab7 regulates primary cilia disassembly through cilia excision
نویسندگان
چکیده
منابع مشابه
PTEN regulates cilia through Dishevelled
Cilia are hair-like cellular protrusions important in many aspects of eukaryotic biology. For instance, motile cilia enable fluid movement over epithelial surfaces, while primary (sensory) cilia play roles in cellular signalling. The molecular events underlying cilia dynamics, and particularly their disassembly, are not well understood. Phosphatase and tensin homologue (PTEN) is an extensively ...
متن کاملPrimary cilia
The primary cilium was first so named by Sergei Sorokin in 1968.[1] Since the discovery of primary cilium in 1898 by Zimmerman, three major hypotheses for their function have been put forth. The first is that primary cilia are vestigial organelles inherited from an ancestor whose cells had motile cilia and now are of no purpose in multicellular organisms. The second is that they are involved in...
متن کاملPrimary cilia in bone.
lization. This independence of calcium and PGE 2 has been reported previously and suggests that there are multiple mechanisms by which bone cells sense their mechanical environment. These findings are currently in press in the Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. by oscillatory fluid flow via intracellular calcium mobilization and activation of ...
متن کاملDynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision
The life cycle of a primary cilium begins in quiescence and ends prior to mitosis. In quiescent cells, the primary cilium insulates itself from contiguous dynamic membrane processes on the cell surface to function as a stable signaling apparatus. Here, we demonstrate that basal restriction of ciliary structure dynamics is established by the cilia-enriched phosphoinositide 5-phosphatase, Inpp5e....
متن کاملDISC1 Regulates Primary Cilia That Display Specific Dopamine Receptors
BACKGROUND Mutations in the DISC1 gene are strongly associated with major psychiatric syndromes such as schizophrenia. DISC1 encodes a cytoplasmic protein with many potential interaction partners, but its cellular functions remain poorly understood. We identified a role of DISC1 in the cell biology of primary cilia that display disease-relevant dopamine receptors. METHODOLOGY/PRINCIPAL FINDIN...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2019
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201811136